Poly(caprolactone)-pluronic- poly(caprolactone) amphiphilic copolymer nanoparticles for controlled 5-fluorouracil release
In this work amphiphilic triblock copolymers pol(ζ-caprolactone)/ Pluronic/ poly(ζ-caprolactone) were synthesized by Lipase B catalyzed ring-opening polymerization of ε- caprolactone monomer initiated by Pluronic. Nanoparticles were prepared using prepared copolymers by solvent evaporation method. 5- Fluorouracil as a model drug was loaded in these nanoparticles to investigate the drug release behavior. The properties of the prepared nanoparticles were extensively studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The particle sizes obtained by dynamic light scattering of these nanoparticles were in the range of 100-115 nm, and increased as the hydrophobic property of the nanoparticles increased. TEM showed that the nanoparticles were in a well-defined spherical shape with a uniform size distribution. We also investigated the entrapment and in vitro release behavior in presence of ultrasound for controlled release, which indicated that the release speed of 5-FU could be well-controlled.
Faculty of Applied Health Sciences Technology
Physical Sciences, General Computer Science, General Engineering
Indexed in Scopus
Indexed in Web Of Science
5-fluorouracil, Controlled release, Nanoparticles, Poly(ζ-caprolactone) (PCL)
Mohamed, Moustafa M.; El-Fattah, Ahmad Abd; Ramadan, Heba S.; Gad, Aly; and Gado, Karim, "Poly(caprolactone)-pluronic- poly(caprolactone) amphiphilic copolymer nanoparticles for controlled 5-fluorouracil release" (2011). Faculty of Applied Health Sciences Technology. 113.