Title

Egyptian Olea europaea leaves bioactive extract: Antibacterial and wound healing activity in normal and diabetic rats

Document Type

Article

Abstract

Background and aim: In vitro activity evaluation of Egyptian Olea europaea leaves extracts, and in vivo healing activity assessment of the newly prepared ointment of Olea europaea leaves extracts mingled with Shea butter. Experimental procedure: Different extraction methods and solvents were used to extract Egyptian Olea europaea bioactive agent(s). Antibacterial, scavenging activity and in-vivo evaluation of wound repair potentiality of Olea europaea extract were examined in normal and diabetic experimental rat models with induced circular excisions. Results and conclusion: Olive leaves extract of Tanta was selected as the most active agent against Methicillin-resistant S. aureus (MRSA), with MIC value 15.6 μg/ml. Moreover, checkerboard dilution technique approved that the interaction between Tanta LEM crude extract and Ciprofloxacin was synergistic. Scavenging activity of the extract against DPPH free radicals was 87.55% at concentration of 50 μg/ml. In vivo normal and diabetic experimental rats treated with Shea butter: Tanta LEM extract (1:3 w/v) showed the maximum wound contraction and healing activity.

Publication Date

9-1-2021

Faculty

Faculty of Applied Health Sciences Technology

Subject Area

Health Sciences, General Medicine

Indexed in Scopus

yes

Indexed in Web Of Science

yes

DOI

https://doi.org/10.1016/j.jtcme.2021.02.008

Volume

11

Keywords

Antimicrobial activity, MRSA, Olea europaea, Oleuropein, Wound healing

eISSN

22254110

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