Title

Quantitative optimisation of MRI contrast agent dose using response surface modelling

Document Type

Article

Abstract

Nevertheless that Contrast Agent (CA) has adverse effect on patients, besides its relatively high cost, it is used in 30-40% of Magnetic Resonance Imaging (MRI) for tissue specificity. Our aim is to optimise (minimise) needed dose by studying the efficacy of magnetising CA before scanning on its signal-to-noise ratio (SNR). One set of seven samples of gadodiamide in saline were magnetised with a permanent magnet before being placed in phantoms (S1), in addition to another identical set but not magnetised (S2) (reference set) are imaged in a closed 1.5 T MRI. Both sets of Phantoms are with different CA concentration (0, 0.33, 0.66, 0.99, 1.3, 1.7, 2 mM). S1 is scanned from 0-5 hours after magnetisation, while S2 scanned once. By implementing RSM, results shows that CA could be decreased by 28% to 37.60% if externally magnetised before scanning.

Publication Date

1-1-2016

Faculty

Faculty of Applied Health Sciences Technology

Subject Area

Physical Sciences, General Engineering

Indexed in Scopus

yes

Indexed in Web Of Science

yes

DOI

https://doi.org/10.1504/IJBET.2016.078990

Volume

22

Keywords

Gadodiamide, Liver imaging, Magnetised water, Surface fitting

ISSN

17526418

eISSN

17526426

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