Title

Volatile organic compounds of biofluids for detecting lung cancer by an electronic nose based on artificial neural network

Document Type

Article

Abstract

Lung cancer (LC) incidence represents 11.5% of all new cancers, resulting in 1.72 million deaths worldwide in 2015. With the aim to investigate the capability of the electronic nose (e-nose) technology for detecting and differentiating complex mixtures of volatile organic compounds in biofluids ex-vivo, we enrolled 50 patients with suspected LC and 50 matching controls. Tissue biopsy was taken from suspicious lung mass for histopathological evaluation and blood, exhaled breath, and urine samples were collected from all participants and qualitatively processed using e-nose. Odor-print patterns were further analysed using the principal component analysis (PCA) and artificial neural network (ANN) analysis. Adenocarcinoma, non-small cell LC and squamous cell carcinoma were the predominant pathological types among LC patients. PCA cluster-plots showed a clear distinction between LC patients and controls for all biological samples; where the overall success ratios of classification for principal components #1 and #2 were: 95.46, 82.01, and 91.66% for blood, breath and urine samples, respectively. Moreover, ANN showed a better discrimination between LC patients and controls with success ratios of 95.74, 91.67 and 100% for blood, breath and urine samples, respectively. The e-nose is an easy noninvasive tool, capable of identifying LC patients from controls with great precision.

Publication Date

1-1-2019

Faculty

Faculty of Applied Health Sciences Technology

Subject Area

Life Sciences, Neuroscience, Agricultural and Biological Sciences, Pharmacology, Toxicology, Pharmaceutical Science, Biochemistry, Genetics, Molecular Biology

Indexed in Scopus

yes

Indexed in Web Of Science

yes

DOI

https://doi.org/10.32725/jab.2018.006

Volume

17

Keywords

Artificial Neural Network, Biological Fluids, Electronic Nose, Lung Cancer, Principal Component Analysis, Urine

ISSN

1214021X

eISSN

12140287

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