Title

The significance of nanoparticles in brain cancer diagnosis and treatment: modeling and simulation

Document Type

Article

Abstract

A numerical analysis of specific absorption rate (SAR) and temperature distributions in a realistic human head model is presented in this study. The key challenge is to rise cancer temperature to an optimal temperature without heating nearby healthy tissues. The model's uniqueness is that it captures the effect of nanoparticles on both brain cancer diagnosis and treatment. A realistic human head model with a cancerous brain segmented from 2D magnetic resonance imaging (MRI) gained from an actual patient using 3D Slicer, modeled, and simulated using CST-Microwave Studio, and illuminated by Archimedes spiral antenna. At frequencies of 2450 MHz and 915 MHz, the model simulated the absence and presence of various nanoparticles. The obtained results suggest that when using nanoparticles, it is possible to achieve sufficient energy deposition and temperature rise to therapeutic values (greater than 42 °C) in brain cancers using the proposed noninvasive hyperthermia system at 915 MHz frequency, especially for gold nanoparticles, without harming surrounding healthy tissue. Our research might pave the way for a clinical applicator prototype that can heat brain cancer.

Publication Date

4-22-2022

Faculty

Faculty of Applied Health Sciences Technology

Subject Area

Physical Sciences, General Chemical Engineering, General Materials Science, General Computer Science, General Engineering, Health Sciences, General Medicine, Life Sciences, Biochemistry, Genetics, Molecular Biology

Indexed in Scopus

yes

DOI

https://doi.org/10.1088/2057-1976/ac6629

Volume

8

Keywords

antenna, brain cancer, hyperthermia, modelling of microwave systems, nanoparticles

eISSN

20571976

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