Document Type
Article
Abstract
Toxoplasma gondii (T. gondii) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids 3a–c were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol 1 and sulfa drug azides 2a–c. The newly synthesized click products were fully characterized using different spectroscopic experiments and were loaded onto chitosan nanoparticles to form novel nanoformulations for further anti-Toxoplasma investigation. The current study proved the anti-Toxoplasma effectiveness of all examined compounds in experimentally infected mice. Relative to sulfadiazine, the synthesized sulfonamide-1,2,3-triazole (3c) nanoformulae demonstrated the most promising result for toxoplasmosis treatment as it resulted in 100% survival, 100% parasite reduction along with the remarkable histopathological improvement in all the studied organs.
Publication Date
4-1-2022
Faculty
Faculty of Applied Health Sciences Technology
Subject Area
Life Sciences, Biochemistry, Genetics, Molecular Biology, Physical Sciences, General Chemical Engineering, General Chemistry, General Computer Science
Indexed in Scopus
yes
DOI
https://doi.org/10.3390/ijms23084241
Volume
23
Keywords
1, 2, 3-triazoles, nanoformulation, sulfadiazine analogues, Toxoplasma gondii
ISSN
16616596
eISSN
14220067
Recommended Citation
Aljohani, Faizah S.; Rezki, Nadjet; Aouad, Mohamed R.; Elwakil, Bassma H.; Hagar, Mohamed; Sheta, Eman; Mogahed, Nermine Mogahed Fawzy Hussein; Bardaweel, Sanaa K.; and Hagras, Nancy Abd Elkader, "Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents" (2022). Faculty of Applied Health Sciences Technology. 71.
https://pks.pua.edu.eg/applied_health_publications/71