Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents
Toxoplasma gondii (T. gondii) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids 3a–c were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol 1 and sulfa drug azides 2a–c. The newly synthesized click products were fully characterized using different spectroscopic experiments and were loaded onto chitosan nanoparticles to form novel nanoformulations for further anti-Toxoplasma investigation. The current study proved the anti-Toxoplasma effectiveness of all examined compounds in experimentally infected mice. Relative to sulfadiazine, the synthesized sulfonamide-1,2,3-triazole (3c) nanoformulae demonstrated the most promising result for toxoplasmosis treatment as it resulted in 100% survival, 100% parasite reduction along with the remarkable histopathological improvement in all the studied organs.
Faculty of Applied Health Sciences Technology
Life Sciences, Biochemistry, Genetics, Molecular Biology, Physical Sciences, General Chemical Engineering, General Chemistry, General Computer Science
Indexed in Scopus
1, 2, 3-triazoles, nanoformulation, sulfadiazine analogues, Toxoplasma gondii
Aljohani, Faizah S.; Rezki, Nadjet; Aouad, Mohamed R.; Elwakil, Bassma H.; Hagar, Mohamed; Sheta, Eman; Mogahed, Nermine Mogahed Fawzy Hussein; Bardaweel, Sanaa K.; and Hagras, Nancy Abd Elkader, "Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents" (2022). Faculty of Applied Health Sciences Technology. 71.