Multimodality comparative study: Quantitative assessment of MRI contrast agent dose reduction
Contrast agents are used in 30-40% of diagnostic MRI scans. These agents are expensive and cause adverse effects in some patients. One way to reduce the amount of contrast agent needed would be to improve the signal-to-noise ratio (SNR). We hypothesized that pre-magnetizing samples of the paramagnetic contrast agent gadodiamide before scanning would increase the SNR. Samples of gadodiamide in saline were magnetized with a permanent magnet before being placed in a phantom and scanned in either a closed 1.5 T MRI or an open 0.35 T MRI. Samples were scanned 0-5 hours after magnetization. Samples of gadodiamide that had not been magnetized were also scanned. In the 1.5 T instrument, we found an increase in SNR in pre-magnetized samples that was highest three hours after magnetization, up to a 1.8-fold increase at low concentrations of gadodiamide. The improvement in SNR was more modest in the low-field MRI scanner, peaking two hours after magnetization. This relatively simple method has the potential to reduce the amount of contrast agents needed for diagnostic MRI scans.
Faculty of Applied Health Sciences Technology
Physical Sciences, General Chemical Engineering, General Engineering, Life Sciences, Biochemistry, Genetics, Molecular Biology
Indexed in Scopus
Indexed in Web Of Science
Gadodiamide, Liver imaging, Magnetized water, Response surface methodology
Badway, S. M.; Fkirin, M. A.; and Barakat, E. H., "Multimodality comparative study: Quantitative assessment of MRI contrast agent dose reduction" (2016). Faculty of Applied Health Sciences Technology. 75.