Title

Multimodality comparative study: Quantitative assessment of MRI contrast agent dose reduction

Document Type

Article

Abstract

Contrast agents are used in 30-40% of diagnostic MRI scans. These agents are expensive and cause adverse effects in some patients. One way to reduce the amount of contrast agent needed would be to improve the signal-to-noise ratio (SNR). We hypothesized that pre-magnetizing samples of the paramagnetic contrast agent gadodiamide before scanning would increase the SNR. Samples of gadodiamide in saline were magnetized with a permanent magnet before being placed in a phantom and scanned in either a closed 1.5 T MRI or an open 0.35 T MRI. Samples were scanned 0-5 hours after magnetization. Samples of gadodiamide that had not been magnetized were also scanned. In the 1.5 T instrument, we found an increase in SNR in pre-magnetized samples that was highest three hours after magnetization, up to a 1.8-fold increase at low concentrations of gadodiamide. The improvement in SNR was more modest in the low-field MRI scanner, peaking two hours after magnetization. This relatively simple method has the potential to reduce the amount of contrast agents needed for diagnostic MRI scans.

Publication Date

2-1-2016

Faculty

Faculty of Applied Health Sciences Technology

Subject Area

Physical Sciences, General Chemical Engineering, General Engineering, Life Sciences, Biochemistry, Genetics, Molecular Biology

Indexed in Scopus

yes

Indexed in Web Of Science

yes

DOI

https://doi.org/10.4015/S1016237216500010

Volume

28

Keywords

Gadodiamide, Liver imaging, Magnetized water, Response surface methodology

ISSN

10162372

Share

COinS