The role of Beta Catenin and Platelet derived growth factor antibodies in head and neck intermediate grade soft tissue tumors
Background: Intermediate soft tissue tumors were included in the new WHO classification of soft tissue tumors. They were addressed as locally aggressive tumors with reports of their recurrence or even malignant transformation. This study was conducted to detect the immunoepxression of Beta Catenin and Platelet Derived Growth Factor in order to predict their potential for malignant transformation. Methods: Twenty three different intermediate soft tissue tumors were included as well as three recurrent cases diagnosed as fibrosarcoma. All lesions were prepared and were subjected to Beta Catenin and Platelet Derived Growth Factor antibodies. Results: From the 26 selected cases, 9 were Juvenile fibromatosis, 5 were haemangiopericytoma. 9 were desmoplastic fibroma 3 of which showed recurrence and were diagnosed as Fibrosarcoma. All cases of jeuvenile fibromatosis, desmoplastic fibroma and fibrosarcoma, showed positive nuclear reaction to Beta Catenin antibody. Cytoplasmic reaction of Platelet Derived Growth Factor antibody were observed in 6 cases of juvenile fibromatosis and 5 cases of desmoplastic fibroma as well as the 3 cases that showed recurrence in the form of fibrosarcoma.Conclusion: Intermediate tumors have a benign clinical course, but their clinical behavior is unpredictable.
Faculty of Dentistry
Life Sciences, Biochemistry, Genetics, Molecular Biology
Indexed in Scopus
Indexed in Web Of Science
Beta catenin, Intermediate soft tissue tumors, Platelet derived growth factor
Abd El-Latif, Amani N. and Zeitoun, Ibrahim M., "The role of Beta Catenin and Platelet derived growth factor antibodies in head and neck intermediate grade soft tissue tumors" (2012). Faculty of Dentistry. 103.