Title
Montelukast potentiates the antiinflammatory effect of NSAIDs in the rat paw formalin model and simultaneously minimizes the risk of gastric damage
Document Type
Article
Abstract
Objective and design: Montelukast, a cysteinyl leukotriene receptor antagonist, exhibits antiinflammatory action. We tested whether exposure to montelukast plus nonsteroidal antiinflammatory drugs (NSAIDs) elicits better control of paw inflammation in the rat formalin test and improves associated gastric damage. Materials: A total of 46 adult male rats were used in the study. Treatments: We evaluated separate and combined effects of montelukast (20 mg/kg), celecoxib (COX2 inhibitor, 10 mg/kg), and diclofenac (nonselective COX1/COX2 inhibitor, 10 mg/kg) on paw and gastric damage in the rat formalin test. Results: Individual pretreatments of rats with montelukast, diclofenac, or celecoxib partly reduced formalin-induced increases in (i) paw edema, fibrosis, and inflammatory cells, (iii) serum interleukin-6 (IL-6) and leukotrienes (LTB4 and LTD4), and (iv) paw expressions of inducible nitric oxide synthase (iNOS) and COX2. These effects were accentuated in rats treated with montelukast plus diclofenac or montelukast plus celecoxib. Alternatively, montelukast or celecoxib, but not diclofenac, alleviated formalin-evoked gastric damage and increments in tumor necrosis factor-α and decrements in prostaglandin-E2. These advantageous gastric influences were potentiated in rats treated with montelukast plus celecoxib. Conclusions: While montelukast equally enhances antiinflammatory action of diclofenac or celecoxib via downregulating iNOS/COX2/LTs/IL-6 signaling, its gastroprotective action is preferentially potentiated by celecoxib.
Publication Date
9-1-2021
Faculty
Faculty of Dentistry
Subject Area
Life Sciences, General Immunology and Microbiology, Pharmacology, Toxicology, Pharmaceutical Science
Indexed in Scopus
yes
Indexed in Web Of Science
yes
DOI
https://doi.org/10.1007/s00011-021-01492-9
Volume
70
Keywords
Cyclooxygenase, Gastric damage, Inflammation, Montelukast, NSAIDs, Paw inflammation
ISSN
10233830
eISSN
1420908X
Recommended Citation
Abdelhady, Sherien A.; Ali, Mennatallah A.; Al-Shafie, Tamer A.; Abdelmawgoud, Ebtsam M.; Yacout, Dalia M.; and El-Mas, Mahmoud M., "Montelukast potentiates the antiinflammatory effect of NSAIDs in the rat paw formalin model and simultaneously minimizes the risk of gastric damage" (2021). Faculty of Dentistry. 40.
https://pks.pua.edu.eg/dentistry_publications/40