Title

Factors that influence adult neurogenesis as potential therapy

Document Type

Article

Abstract

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders. In addition, adult neurogenesis might also play a role in mood and affective disorders. The factors that regulate adult neurogenesis have been broadly studied. However, the underlying molecular mechanisms of regulating neurogenesis are still not fully defined. In this review, we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine neurogenesis. We will further discuss pre-clinical and clinical studies that have investigated the potential of modulating neurogenesis as therapeutic intervention in neurodegeneration.

Publication Date

2-21-2018

Faculty

Faculty of Pharmacy

Subject Area

Life Sciences, Neuroscience, Health Sciences, General Medicine

Indexed in Scopus

yes

Indexed in Web Of Science

yes

DOI

https://doi.org/10.1186/s40035-018-0109-9

Volume

7

Keywords

Cytokines, Extrinsic factors, Neurotrophins, Niche, Stem cells, Therapy, Transcription factors

eISSN

20479158

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