Title

DNA fingerprinting, biological and chemical investigation of certain Yucca species

Document Type

Article

Abstract

Yucca aloifolia, Y. aloifolia variegata, Y. elephantipes and Y. filamentosa were investigated. DNA sequencing was performed for the four plants and a genomic DNA fingerprint was obtained and provided. The cytotoxic activities against four human cancer cell lines were investigated. The ethanolic extracts of leaves of Y. aloifolia variegata prevailed, especially against liver cancer HepG-2 and breast cancer MCF-7. In vivo assessment of hepatoprotective activity in rats also revealed the hepatoprotective potential of the ethanolic extracts of the four plants against CCl4- induced rats’ liver damage. Qualitative and quantitative analysis of the flavonoid and phenolic content of the promising species was performed using HPLC. The analysis identified and quantified 18 flavonoids and 19 phenolic acids in the different fractions of Y. aloifolia variegata, among which the major flavonoids were hesperidin and kaemp-3-(2-p-coumaroyl) glucose and the major phenolic acids were gallic acid and protocatechuic acid.

Publication Date

11-2-2018

Faculty

Faculty of Pharmacy

Subject Area

Life Sciences, Agricultural and Biological Sciences, Biochemistry, Genetics, Molecular Biology, Physical Sciences, General Chemistry

Indexed in Scopus

yes

Indexed in Web Of Science

yes

DOI

https://doi.org/10.1080/14786419.2017.1423311

Volume

32

Keywords

cytotoxicity, DNA, flavonoids, hepatoprotective, HPLC, phenolics, Yucca

ISSN

14786419

eISSN

14786427

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